A painless plea from me

Please hurry! Please hurry! Time is running out. In about two weeks I will once again become a human pincushion and I would love to avoid the needle. You are my only hope, you scientists at the University of Minnesota. Without you, on June 2 I will settle into the dentist’s chair and get my full dose of topical anesthesia –– right in the cheek and gums when I have my first tooth pulled to make way for a dental implant.

How can these scientists help me? They have just announced a breakthrough: An anesthesia inhaler that could one day replace that needle.

I know it’s impossible that the device could miraculously make it into the health care delivery system, in the next two weeks, but you can’t blame me for dreaming…

Scientists are reporting evidence that a common local anesthetic, when administered to the nose as nose drops or a nasal spray, travels through the main nerve in the face and collects in high concentrations in the teeth, jaw, and structures of the mouth.

The discovery could lead to a new generation of intranasal drugs for noninvasive treatment for dental pain, migraine, and other conditions, the scientists suggest in American Chemical Society’s bi-monthly journal Molecular Pharmaceutics. The article is scheduled for the journal’s May-June issue.

William H. Frey II, Ph.D., and colleagues note that drugs administered to the nose travel along nerves and go directly to the brain. One of those nerves is the trigeminal nerve, which brings feelings to the face, nose and mouth. Until now, however, scientists never checked to see whether intranasal drugs passing along that nerve might reach the teeth, gums and other areas of the face and mouth to reduce pain sensations in the face and mouth.   

Neil Johnson, working in the labs of Frey and Leah R. Hanson, Ph.D., at Regions Hospital in St. Paul, Minn., found that lidocaine or Xylocaine, sprayed into the noses of laboratory rats, quickly traveled down the trigeminal nerve and collected in their teeth, jaws, and mouths at levels 20 times higher than in the blood or brain. The approach could provide a more effective and targeted method for treating dental pain/anxiety, trigeminal neuralgia (severe facial pain), migraine, and other conditions, the scientists say.

To read more about this innovation, go to painless.     

Image courtesy of iStock

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The American Chemical Society's Office of Public Affairs' new pressroom blog highlights prominent research from ACS' 34 journals. It includes daily commentary on the latest news from ACS' weekly PressPac, including video and audio segments from researchers on topics covering chemistry and related sciences. The blog also covers updates on ACS' awards, the national meetings and other general news from the world's largest scientific society.